(S,R,S)-AHPC-PEG2-C2-azide

Azides Click chemistry Copper-free click chemistry PROTAC
Cat. # Quantity Price Lead time
4530-25mg 25 mg $189 in stock
4530-100mg 100 mg $529 in stock
4530-500mg 500 mg $1598 in stock
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Proteolysis targeting chimeras (PROTACs) are cell-permeable heterobifunctional molecules that can remove specific proteins from the cell. One end of such molecule contains a ligand to bind to the target, and the second end recruits the E3 ligase complex. Close proximity results in substrate polyubiquitination and subsequent protein degradation by cellular proteasome.

(S,R,S)-AHPC-C2-azide is a protein degrader building block for the synthesis of molecules for targeted protein degradation and PROTAC technologies. This conjugate contains a von Hippel-Lindau (VHL)-recruiting ligand and a PEG2-C2 crosslinker with an azide function group, which can be conjugated to alkyne-functionalized linkers and target protein ligands through click chemistry reactions.

(S,R,S)-AHPC-PEG2-C2-azide, 4530-25mg
(S,R,S)-AHPC-PEG2-C2-azide, 4530-25mg
(S,R,S)-AHPC-PEG2-C2-azide, 4530-25mg
Structure of (S,R,S)-AHPC-PEG2-C2-azide
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Thalidomide-containing building block with PEG2-linker and carboxylic group for conjugation with amino-functionalized linkers and target protein ligands.
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Thalidomide-O-PEG2-azide

Thalidomide-containing building block with PEG2-linker and azide function group for conjugation with alkyne-functionalized linkers and target protein ligands through click chemistry reactions.

Thalidomide-carboxylic acid

Thalidomide-containing building block with carboxylic acid functionality for convenient PROTAC molecule assembly by attachment amino-functionalized linkers and ligands to thalidomide via 4-O-position.

General properties

Appearance: yellow glassy oil
Molecular weight: 615.75
CAS number: 2597167-22-9
Molecular formula: C29H41N7O6S
Solubility: methanol, ethyl acetate, DCM, THF, DMF, DMSO
Quality control: NMR 1H and HPLC-MS (95+%)
Storage conditions: 24 months after receival at -20°C in the dark. Transportation: at room temperature for up to 3 weeks. Desiccate.
MSDS: Download
Product specifications
This Product is offered and sold for research purposes only. It has not been tested for safety and efficacy in food, drug, medical device, cosmetic, commercial or any other use. Supply does not express or imply authorization to use for any other purpose, including, without limitation, in vitro diagnostic purposes, in the manufacture of food or pharmaceutical products, in medical devices or in cosmetic products.
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