PROTAC in Applications
Proteolysis targeting chimeras (PROTACs) are cell-permeable heterobifunctional molecules that can remove specific proteins from the cell. One end of such molecule contains a ligand to bind to the target, and the second end recruits the E3 ligase complex. Close proximity results in substrate polyubiquitination and subsequent protein degradation by cellular proteasome.
(S,R,S)-AHPC-amido-C2-carboxylic acid
VHL ligand containing short carbon alkyl linker (C2) and terminal carboxylic group for conjugation with amino-functionalized linkers and target protein ligands.
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| Cat. # | Quantity | Price | Lead time | Buy this product |
|---|---|---|---|---|
| 4528-25mg | 25 mg | $189 | in stock | |
| 4528-100mg | 100 mg |
$529
|
in stock | |
| 4528-500mg | 500 mg |
$1698
|
in stock |
(S,R,S)-AHPC-PEG2-C2-amine
Degrader building block containing an E3 ligase ligand with linker and amino group for conjugation with other functionalized linkers and target protein ligands.
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| Cat. # | Quantity | Price | Lead time | Buy this product |
|---|---|---|---|---|
| 4537-25mg | 25 mg | $189 | in stock | |
| 4537-100mg | 100 mg |
$489
|
in stock | |
| 4537-500mg | 500 mg |
$1880
|
in stock |
(S,R,S)-AHPC-PEG2-C2-azide
Degrader building block containing an E3 ligase ligand with linker and azide group, which can be conjugated to alkyne-functionalized linkers and target protein ligands through click chemistry reactions.
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| Cat. # | Quantity | Price | Lead time | Buy this product |
|---|---|---|---|---|
| 4530-25mg | 25 mg | $189 | in stock | |
| 4530-100mg | 100 mg |
$529
|
in stock | |
| 4530-500mg | 500 mg |
$1598
|
in stock |
Thalidomide-carboxylic acid
Thalidomide-containing building block with carboxylic acid functionality for convenient PROTAC molecule assembly by attachment amino-functionalized linkers and ligands to thalidomide via 4-O-position.
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| Cat. # | Quantity | Price | Lead time | Buy this product |
|---|---|---|---|---|
| 4169-100mg | 100 mg | $160 | in stock | |
| 4169-500mg | 500 mg |
$510
|
in stock | |
| 4169-1g | 1 g |
$740
|
in stock |
Thalidomide-O-PEG2-amine
Thalidomide-containing building block with PEG2-linker and amino group for conjugation with other functionalized linkers and target protein ligands.
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| Cat. # | Quantity | Price | Lead time | Buy this product |
|---|---|---|---|---|
| 4401-100mg | 100 mg |
$425
|
in stock | |
| 4401-250mg | 250 mg |
$749
|
in stock |
Thalidomide-O-PEG2-azide
Thalidomide-containing building block with PEG2-linker and azide function group for conjugation with alkyne-functionalized linkers and target protein ligands through click chemistry reactions.
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| Cat. # | Quantity | Price | Lead time | Buy this product |
|---|---|---|---|---|
| 4154-25mg | 25 mg | $189 | in stock | |
| 4154-100mg | 100 mg |
$489
|
in stock |
Thalidomide-O-PEG2-carboxylic acid
Thalidomide-containing building block with PEG2-linker and carboxylic group for conjugation with amino-functionalized linkers and target protein ligands.
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| Cat. # | Quantity | Price | Lead time | Buy this product |
|---|---|---|---|---|
| 4192-25mg | 25 mg | $145 | in stock | |
| 4192-100mg | 100 mg |
$425
|
in stock |
VHL Ligand 1 dihydrochloride
VHL Ligand 1 is a building block for synthesizing proteolysis-targeting chimera (PROTAC) molecules.
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| Cat. # | Quantity | Price | Lead time | Buy this product |
|---|---|---|---|---|
| 4065-250mg | 250 mg | $175 | in stock | |
| 4065-500mg | 500 mg | $258 | in stock | |
| 4065-1g | 1 g |
$469
|
in stock |
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