Copper-free click chemistry in Applications

Copper-free click chemistry reactions include cycloadditions for bioconjugation that do not rely on the use of transition metal catalyst, as opposed to traditional copper catalyzed сlick chemistry.

These reactions include the strain promoted alkyne-azide cycloaddition (SPAAC) that involves strained cycloalkyne, and azide. Relief of the sterical strain provides a driving force for this reaction.

Scheme of SPAAC copper-free click chemistry reaction

DBCO (ADIBO) cycloalkynes are among the most reactive yet stable. The reaction yields two regioisomers that usually cannot be separated, therefore this does not lead to peak doubling in HPLC.

Another process is TCO ligation (tetrazine - trans-cyclooctene ligation) which is also powered by sterical strain. Unlike SPAAC, this is [4+2]-cycloaddition yielding 6-membered ring. TCO ligation is among the fastest reactions used for the bioconjugation.

Scheme of TCO (trans-cyclooctene tetrazine) ligation reaction

Both these reactions are very biocompatible as they do not require to use a metal catalyst, they are fast, and orthogonal in case of DBCO cycloalkynes (i.e., it is possible to run two reaction in one mixture without interference).

Lumiprobe manufactures a number of reagents for copper-free click-chemistry, for both SPAAC, and TCO ligation.

(S,R,S)-AHPC-PEG2-C2-azide

Degrader building block containing an E3 ligase ligand with linker and azide group, which can be conjugated to alkyne-functionalized linkers and target protein ligands through click chemistry reactions.
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Cat. # Quantity Price Lead time
4530-25mg 25 mg $189 in stock
4530-100mg 100 mg $529 in stock
4530-500mg 500 mg $1598 in stock
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4AZP (4-Azido-L-phenylalanine)

Unnatural L-phenylalanine derivative with an azide moiety for nascent protein synthesis detection via copper-catalyzed and copper-free click chemistry.
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Cat. # Quantity Price Lead time
3415-100mg 100 mg $125 in stock
3415-500mg 500 mg $625 in stock
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Ac4GalNAz (N-Azidoacetylgalactosamine-tetraacylated)

An azide-functionalized monosaccharide for metabolic labeling and studying the cellular trafficking of labeled proteins and proteomic analysis.
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Cat. # Quantity Price Lead time
3706-5mg 5 mg $129 in stock
3706-25mg 25 mg $240 in stock
3706-100mg 100 mg $630 in stock
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Ac4GlcNAz (N-Azidoacetylglucosamine-tetraacylated)

An azide-functionalized monosaccharide for metabolic labeling and studying the cellular trafficking of labeled proteins and proteomic analysis.
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Cat. # Quantity Price Lead time
3662-5mg 5 mg $129 in stock
3662-25mg 25 mg $240 in stock
3662-100mg 100 mg $630 in stock
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Ac4ManNAz (N-Azidoacetylmannosamine-tetraacylated)

An azide-functionalized monosaccharide for metabolic labeling and studying the cellular trafficking of labeled proteins and proteomic analysis.
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Cat. # Quantity Price Lead time
3159-5mg 5 mg $129 in stock
3159-25mg 25 mg $240 in stock
3159-100mg 100 mg $630 in stock
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AF 430 tetrazine

Tetrazine derivative of AF 430 fluorescent dye suitable for in vitro cell labeling.
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Cat. # Quantity Price Lead time
108E0 1 mg $125 in stock
208E0 5 mg $325 in stock
308E0 10 mg $480 in stock
408E0 25 mg $950 in stock
508E0 50 mg $1625 in stock
608E0 100 mg $2090 in stock
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AF 488 DBCO

Dibenzocyclooctyne (DBCO, ADIBO) containing the green fluorophore AF 488 for labeling azide-tagged biomolecules inside live cells, whole organisms, and inanimate samples. Pure 5-isomer.
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Cat. # Quantity Price Lead time
118F0 1 mg $140 in stock
218F0 5 mg $450 in stock
418F0 25 mg $1460 in stock
518F0 50 mg $1890 in stock
618F0 100 mg $2640 in stock
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AF 488 TCO

AF 488-containing derivative of trans-cyclooctene (TCO) for conjugation with tetrazine via the inverse electron-demand Diels-Alder cycloaddition reaction (IEDDA).
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Cat. # Quantity Price Lead time
118H0 1 mg $199 in stock
218H0 5 mg $649 in stock
418H0 25 mg $1789 in stock
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AF 555 DBCO

Dibenzocyclooctyne (DBCO, ADIBO) containing the yellow fluorophore AF 555 for labeling azide-tagged biomolecules inside live cells, whole organisms, and inanimate samples.
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Cat. # Quantity Price Lead time
1K8F0 1 mg $140 in stock
2K8F0 5 mg $450 in stock
4K8F0 25 mg $1460 in stock
5K8F0 50 mg $1890 in stock
6K8F0 100 mg $2990 in stock
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AF 568 DBCO

Dibenzocyclooctyne (DBCO, ADIBO) containing the orange fluorophore AF 568 for cooper-free labeling azide-tagged biomolecules inside live cells, whole organisms, and inanimate samples.
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Cat. # Quantity Price Lead time
1158F0 1 mg $140 in stock
2158F0 5 mg $450 in stock
4158F0 25 mg $1460 in stock
5158F0 50 mg $1890 in stock
6158F0 100 mg $2990 in stock
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AF 647 DBCO

Dibenzocyclooctyne (DBCO, ADIBO) derivative of the far red fluorophore AF 647 for labeling azide-tagged biomolecules inside live cells, whole organisms, and inanimate samples.
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Cat. # Quantity Price Lead time
1G8F0 1 mg $140 in stock
2G8F0 5 mg $450 in stock
4G8F0 25 mg $1460 5 days
5G8F0 50 mg $1890 in stock
6G8F0 100 mg $2990 in stock
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AHA (L-Azidohomoalanine)

Noncanonical amino acid analog of methionine with an azide moiety for nascent protein synthesis detection via copper-catalyzed and copper-free click chemistry.
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Cat. # Quantity Price Lead time
3799-25mg 25 mg $125 in stock
3799-100mg 100 mg $235 in stock
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AmdU (5-Azidomethyl-2'-deoxyuridine)

Azidomethyldeoxyuridine (AmdU) is an azide-contained nucleoside that is incorporated into nascent DNA by cellular polymerases. The azide groups attached to DNA this way can be subsequently modified with alkynes or cycloalkynes via copper-catalyzed or strain-promoted click reaction.
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Cat. # Quantity Price Lead time
B1540 5 mg $120 in stock
D1540 25 mg $255 in stock
F1540 100 mg $890 in stock
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Azide-PEG3-tetrazine

A hydrophilic bifunctional linker with azide and tetrazine function groups flanking PEG3 (triethylene glycol) spacer.
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Cat. # Quantity Price Lead time
2798-250mg 250 mg $549 in stock
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BDP® 558/568 DBCO

BDP 558/568 DBCO is a bright and photostable dye with emission in the yellow spectrum range. It contains a cyclooctyne substituting group (i.e. DBCO), which can react with various azides in Click Chemistry reactions.
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Cat. # Quantity Price Lead time
174F0 1 mg $125 in stock
274F0 5 mg $260 in stock
374F0 10 mg $325 in stock
474F0 25 mg $510 in stock
574F0 50 mg $895 in stock
674F0 100 mg $1490 in stock
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BDP® 558/568 tetrazine

Stable fluorophore that can be conjugated with trans-cyclooctene derivatives of biomolecules for their visualization.
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Cat. # Quantity Price Lead time
A74E0 1 mg $125 in stock
B74E0 5 mg $260 in stock
C74E0 10 mg $325 in stock
D74E0 25 mg $510 in stock
E74E0 50 mg $895 in stock
F74E0 100 mg $1490 in stock
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BDP® 576/589 tetrazine

Tetrazine derivative of BDP 576/589 hydrophobic dye for conjugation with trans-cyclooctenes and cyclopropenes in the TCO ligation reaction.
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Cat. # Quantity Price Lead time
1G4E0 1 mg $110 in stock
2G4E0 5 mg $290 in stock
3G4E0 10 mg $450 in stock
4G4E0 25 mg $690 in stock
5G4E0 50 mg $1270 in stock
6G4E0 100 mg $1990 in stock
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BDP® 581/591 DBCO

BDP 581/591 is a borondipyrromethene dye that can be used not only as a fluorescent dye, but also as a ROS probe. It can be conjugated with azides using copper-free click chemistry.
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Cat. # Quantity Price Lead time
A64F0 1 mg $125 in stock
B64F0 5 mg $260 in stock
C64F0 10 mg $325 in stock
D64F0 25 mg $510 in stock
E64F0 50 mg $895 in stock
F64F0 100 mg $1490 in stock
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BDP® 581/591 tetrazine

BDP 581/591 is a borondipyrromethene dye with a tetrazine group for the inverse electron demand Diels-Alder (IEDDA) ligation.
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Cat. # Quantity Price Lead time
164E0 1 mg $110 in stock
264E0 5 mg $290 in stock
464E0 25 mg $690 in stock
564E0 50 mg $1270 in stock
664E0 100 mg $1990 in stock
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BDP® 630/650 tetrazine

BDP 630/650 is a borondipyrromethene dye for Cyanine5 channel. This is a tetrazine derivative for the coupling with strained cycloalkenes.
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Cat. # Quantity Price Lead time
154E0 1 mg $110 in stock
254E0 5 mg $290 in stock
454E0 25 mg $690 in stock
554E0 50 mg $1270 in stock
654E0 100 mg $1990 in stock
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BDP® 650/665 DBCO

This red-fluorescent dye contains a substituting group for copper-free click chemistry.
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Cat. # Quantity Price Lead time
AE4F0 1 mg $125 in stock
BE4F0 5 mg $260 in stock
CE4F0 10 mg $325 in stock
DE4F0 25 mg $510 in stock
EE4F0 50 mg $895 in stock
FE4F0 100 mg $1490 in stock
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BDP® FL DBCO

BDP FL DBCO is a dye cyclooctyne for copper-free click chemistry reactions with azides. Its absorption and emission wavelengths correspond to those of fluorescein (FAM), but BDP FL is significantly more photostable.
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Cat. # Quantity Price Lead time
A14F0 1 mg $125 in stock
B14F0 5 mg $260 in stock
C14F0 10 mg $325 in stock
D14F0 25 mg $510 in stock
E14F0 50 mg $895 in stock
F14F0 100 mg $1490 in stock
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BDP® FL tetrazine

BDP FL tetrazine (methyltetrazine) is a reactive dye for the inverse electron demand Diels-Alder (IEDDA) reaction with trans-cyclooctenes, cyclopropenes, and other strained cycloolefines. BDP FL is a bright and photostable dye for the 488 nm fluorescein (FAM) channel.
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Cat. # Quantity Price Lead time
114E0 1 mg $110 in stock
214E0 5 mg $290 in stock
414E0 25 mg $690 in stock
514E0 50 mg $1270 in stock
614E0 100 mg $1990 in stock
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BDP® R6G DBCO

A derivative of BDP R6G dye with azodibenzocyclooctyne (DBCO or ADIBO) for copper-free click chemistry conjugation with azides.
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Cat. # Quantity Price Lead time
A44F0 1 mg $125 in stock
B44F0 5 mg $260 in stock
C44F0 10 mg $325 in stock
D44F0 25 mg $510 in stock
E44F0 50 mg $895 in stock
F44F0 100 mg $1490 in stock
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BDP® R6G tetrazine

BDP R6G tetrazine is a borondipyrromethene dye with absorption and emission wavelengths similar to those of rhodamine 6G. It contains a tetrazine fragment for IEDDA ligation.
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Cat. # Quantity Price Lead time
144E0 1 mg $110 in stock
244E0 5 mg $290 in stock
444E0 25 mg $690 in stock
544E0 50 mg $1270 in stock
644E0 100 mg $1990 in stock
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BDP® TMR DBCO

This yellow-orange-fluorescent boron dipyrromethene dye contains a DBCO substituting group for participation in click chemistry reactions.
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Cat. # Quantity Price Lead time
124F0 1 mg $125 in stock
224F0 5 mg $260 in stock
424F0 25 mg $510 in stock
524F0 50 mg $895 in stock
624F0 100 mg $1490 in stock
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BDP® TMR tetrazine

A fluorophore for the TAMRA channel with a functional group that can form conjugates in click chemistry reactions (IEDDA ligation) .
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Cat. # Quantity Price Lead time
124E0 1 mg $125 in stock
224E0 5 mg $260 in stock
424E0 25 mg $510 in stock
524E0 50 mg $895 in stock
624E0 100 mg $1490 in stock
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BDP® TR DBCO

A dye with a dibenzocyclooctyne substituting group for the ROX channel.
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Cat. # Quantity Price Lead time
1D4F0 1 mg $125 in stock
2D4F0 5 mg $260 in stock
4D4F0 25 mg $510 in stock
5D4F0 50 mg $895 in stock
6D4F0 100 mg $1490 in stock
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BDP® TR tetrazine

BDP TR is a borondipyrromethene fluorophore for the ROX channel. The dye produces bright fluorescent emission. Tetrazines are reactive components for the conjugation with strained cycloalkenes.
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Cat. # Quantity Price Lead time
134E0 1 mg $110 in stock
234E0 5 mg $290 in stock
434E0 25 mg $690 in stock
534E0 50 mg $1270 in stock
634E0 100 mg $1990 in stock
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Biotin-PEG4-tetrazine

Biotin tetrazine is a reagent for copper-free click chemistry labeling with biotin, a well-known affinity probe to streptavidin.
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Cat. # Quantity Price Lead time
3797-25mg 25 mg $210 in stock
3797-250mg 250 mg $1190 in stock
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Cyanine3 DBCO

Cyanine3 dibenzocyclooctyne (DBCO, or ADIBO) is a cycloalkyne dye derivative for copper-free click chemistry.
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Cat. # Quantity Price Lead time
A10F0 1 mg $125 in stock
B10F0 5 mg $260 in stock
C10F0 10 mg $325 in stock
D10F0 25 mg $510 in stock
E10F0 50 mg $895 in stock
F10F0 100 mg $1490 in stock
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Cyanine3 tetrazine

Tetrazine derivative of the fluorophore Cyanine3. Tetrazines react extremely quickly with strained alkenes (such as trans-cyclooctenes, cyclopropenes), and some strained alkynes.
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Cat. # Quantity Price Lead time
110E0 1 mg $125 in stock
210E0 5 mg $260 in stock
410E0 25 mg $510 in stock
510E0 50 mg $895 in stock
610E0 100 mg $1490 in stock
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Cyanine3-PEG4-BCN (exo)

Cyanine3-PEG4-BCN is an ethylene glycol separated linker for the azido-modified molecules for copper-free click conjugation.
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NO items of this product available in stock but you can submit request for bulk.
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Cyanine3.5 DBCO

Cyclooctyne derivative of Cyanine3.5 dye, which easily reacts with various azides resulting in stable conjugates.
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Cat. # Quantity Price Lead time
A20F0 1 mg $125 in stock
B20F0 5 mg $260 in stock
C20F0 10 mg $325 in stock
D20F0 25 mg $510 in stock
E20F0 50 mg $895 in stock
F20F0 100 mg $1490 in stock
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Cyanine3B DBCO

Dibenzocyclooctyne (DBCO, ADIBO) containing Cyanine3B fluorophore for labeling azide-tagged biomolecules inside live cells, whole organisms, and inanimate samples.
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Cat. # Quantity Price Lead time
193F0 1 mg $369 in stock
293F0 5 mg $727 in stock
493F0 25 mg $1950 in stock
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Cyanine3B tetrazine

Cyanine3B dye tetrazine derivative for IEDDA conjugation with strained olefins and terminal alkenes.
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Cat. # Quantity Price Lead time
193E0 1 mg $348 in stock
293E0 5 mg $737 in stock
493E0 25 mg $1950 in stock
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Cyanine5 DBCO

Cyanine5 dye with dibenzocyclooctyne (DBCO) functional group for copper-free click chemistry.
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Cat. # Quantity Price Lead time
A30F0 1 mg $125 in stock
B30F0 5 mg $260 in stock
C30F0 10 mg $325 in stock
D30F0 25 mg $510 in stock
E30F0 50 mg $895 in stock
F30F0 100 mg $1490 in stock
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Cyanine5 tetrazine

Cyanine5 is a universal red emitting dye with a very high extinction coefficient, and good quantum yield. This tetrazine derivative reacts very quickly with trans-cyclooctenes and cyclopropenes with the formation of stable conjugates.
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Cat. # Quantity Price Lead time
130E0 1 mg $125 in stock
230E0 5 mg $260 in stock
430E0 25 mg $510 in stock
530E0 50 mg $895 in stock
630E0 100 mg $1490 in stock
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Cyanine5.5 DBCO

Cyanine5.5 is a far-red / NIR emitting dye that is useful for bioimaging studies. Cyanine5.5 DBCO is a derivative of the dye with a cycloalkyne moiety for copper-free click chemistry.
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Cat. # Quantity Price Lead time
A70F0 1 mg $125 in stock
B70F0 5 mg $260 in stock
C70F0 10 mg $325 in stock
D70F0 25 mg $510 in stock
E70F0 50 mg $895 in stock
F70F0 100 mg $1490 in stock
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Cyanine5.5 tetrazine

A compound containing Cyanine5.5 fluorophore, a far red emitting dye, and tetrazine fragment for the conjugation with trans-cyclooctenes / cyclopropenes via TCO ligation.
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Cat. # Quantity Price Lead time
170E0 1 mg $125 in stock
270E0 5 mg $260 in stock
470E0 25 mg $510 in stock
570E0 50 mg $895 in stock
670E0 100 mg $1490 in stock
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Cyanine7 DBCO

NIR fluorescent dye functionalized with cyclooctyne moiety for copper free click chemistry conjugation with azides.
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Cat. # Quantity Price Lead time
A50F0 1 mg $125 in stock
B50F0 5 mg $260 in stock
C50F0 10 mg $325 in stock
D50F0 25 mg $510 5 days
E50F0 50 mg $895 in stock
F50F0 100 mg $1490 in stock
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Cyanine7 tetrazine

Near infrared Cyanine7 dye derivative containing tetrazine group for TCO ligation.
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Cat. # Quantity Price Lead time
150E0 1 mg $125 in stock
250E0 5 mg $325 in stock
450E0 25 mg $510 in stock
550E0 50 mg $895 in stock
650E0 100 mg $1490 in stock
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Cyanine7.5 tetrazine

Cyanine7.5 tetrazine is a tetrazine derivative for TCO ligation and Diels-Alder reaction containing a NIR fluorophore and suitable for in vivo infrared imaging.
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Cat. # Quantity Price Lead time
160E0 1 mg $125 in stock
260E0 5 mg $325 in stock
460E0 25 mg $510 in stock
560E0 50 mg $895 in stock
660E0 100 mg $1490 in stock
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DBCO-amine trifluoroacetate

Bifunctional linker containing dibenzocyclooctyne (DBCO, ADIBO) for strain-promoted copper-free click reaction (SPAAC) and free amine for the coupling with various electrophilic compounds like activated esters and epoxides.
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Cat. # Quantity Price Lead time
1280-100mg 100 mg $218 in stock
1280-500mg 500 mg $678 in stock
1280-1g 1 g $1200 $1018 in stock
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DBCO-maleimide

Bifunctional linker containing a thiol-reactive maleimide group and an azide-reactive dibenzocyclooctyne moiety.
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Cat. # Quantity Price Lead time
4448-100mg 100 mg $319 in stock
4448-500mg 500 mg $1028 in stock
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DBCO-NHS ester

Azodibenzocyclooctyne (DBCO, ADIBO) reagent for strain-promoted copper-free click chemistry (SPAAC). The reagent contains an NHS ester function for the attachment of the cyclooctyne to various molecules.
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Cat. # Quantity Price Lead time
34720 10 mg $80 in stock
44720 25 mg $110 in stock
54720 50 mg $135 5 days
64720 100 mg $210 $178 in stock
94720 1 g $1000 $970 in stock
K4720 5 g $3570 $2990 in stock
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DBCO-PEG6-NHS ester

A heterobifunctional linker with DBCO and NHS ester function groups flanking PEG6 (hexaethylene glycol).
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Cat. # Quantity Price Lead time
3664-50mg 50 mg $247 in stock
3664-100mg 100 mg $449 in stock
3664-1g 1 g $3490 5 days
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DBCO-STP ester

Activated ester for modification of proteins/antibodies/peptides followed by introduction into copper-free click chemistry reaction.
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Cat. # Quantity Price Lead time
2584-10mg 10 mg $90 in stock
2584-25mg 25 mg $180 in stock
2584-100mg 100 mg $450 in stock
2584-500mg 500 mg $1700 5 days
2584-1g 1 g $3000 in stock
2584-5g 5 g please inquire in stock
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DBCO-TEG phosphoramidite

5'-DBCO-TEG phosphoramidite for the synthesis of DBCO-TEG-modified oligos used in copper-free click reactions.
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Cat. # Quantity Price Lead time
4421-50umol 50 umol $169 21 days
4421-250mg 250 mg $987 21 days
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endo-BCN CE-phosphoramidite

BCN-containing phosphoramidite for the synthesis of oligonucleotides and their labeling using copper-free click reactions.
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Cat. # Quantity Price Lead time
3005-100mg 100 mg $390 in stock
3005-250mg 250 mg $850 in stock
3005-1g 1 g $2380 in stock
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exo-BCN CE-phosphoramidite

BCN-containing phosphoramidite for the synthesis of oligonucleotides and their labeling using copper-free click reactions.
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Cat. # Quantity Price Lead time
4396-250mg 250 mg $790 12 days
4396-1g 1 g $2340 12 days
4396-5g 5 g please inquire 12 days
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FAM DBCO, 6-isomer

Cyclooctyne derivative of fluorescein (FAM) for copper-free click chemistry reaction with azides. Pure 6-isomer of fluorescein.
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Cat. # Quantity Price Lead time
151F0 1 mg $110 in stock
251F0 5 mg $160 in stock
451F0 25 mg $260 in stock
551F0 50 mg $370 in stock
651F0 100 mg $525 in stock
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FAM tetrazine, 5-isomer

FAM tetrazine (methyltetrazine) for the conjugation with trans-cyclooctenes and cyclopropenes. Pure 5-isomer of fluorescein.
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Cat. # Quantity Price Lead time
141E0 1 mg $110 in stock
241E0 5 mg $210 in stock
441E0 25 mg $410 in stock
541E0 50 mg $695 in stock
641E0 100 mg $1190 in stock
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FAM tetrazine, 6-isomer

This molecule is a conjugate of bright fluorophore FAM (fluorescein) and tetrazine, a reactive group that reacts with trans-cycloalkenes in a reaction called IEDDA (inverse electron demand Diels-Alder reaction).
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Cat. # Quantity Price Lead time
151E0 1 mg $110 in stock
251E0 5 mg $210 in stock
451E0 25 mg $410 in stock
551E0 50 mg $695 in stock
651E0 100 mg $1190 in stock
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PEG3-tetrazine

PEG3 tetrazine is a mono-reactive triethyleneglycol with a tetrazine group for IEDDA conjugation with strained olefins.
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Cat. # Quantity Price Lead time
1978-250mg 250 mg $390 in stock
1978-1g 1 g $950 in stock
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ROX DBCO, 5-isomer

ROX (rhodamine X) is a bright rhodamine dye. This is a DBCO (dibenzocyclooctyne) derivative that has high reactivity against azides.
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Cat. # Quantity Price Lead time
112F0 1 mg $110 in stock
212F0 5 mg $210 in stock
412F0 25 mg $410 in stock
512F0 50 mg $695 in stock
612F0 100 mg $1190 in stock
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ROX tetrazine, 5-isomer

A tetrazine derivative of bright red-emitting dye ROX (Rhodamine X, Rhodamine 101) for copper-free bioconjugation. Pure 5-isomer.
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Cat. # Quantity Price Lead time
112E0 1 mg $110 in stock
212E0 5 mg $210 in stock
412E0 25 mg $410 in stock
512E0 50 mg $695 in stock
612E0 100 mg $1190 in stock
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sulfo-Cyanine3 DBCO

sulfo-Cyanine3 DBCO is a cycloalkyne derivative of water-soluble fluorophore sulfo-Cyanine3 for copper-free click chemistry.
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Cat. # Quantity Price Lead time
113F0 1 mg $125 in stock
213F0 5 mg $325 in stock
413F0 25 mg $850 in stock
513F0 50 mg $1490 in stock
613F0 100 mg $1990 in stock
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sulfo-Cyanine3 tetrazine

Water-soluble sulfo-Cyanine3 dye tetrazine derivative for TCO ligation labeling with trans-cyclooctenes.
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Cat. # Quantity Price Lead time
113E0 1 mg $125 in stock
213E0 5 mg $325 in stock
313E0 10 mg $470 in stock
413E0 25 mg $850 in stock
513E0 50 mg $1490 in stock
613E0 100 mg $1990 in stock
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sulfo-Cyanine5 DBCO

Water-soluble cycloalkyne for copper-free click chemistry reaction with azides. A derivative of sulfo-Cyanine5.
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Cat. # Quantity Price Lead time
133F0 1 mg $125 in stock
233F0 5 mg $325 in stock
433F0 25 mg $850 in stock
533F0 50 mg $1490 in stock
633F0 100 mg $1990 in stock
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sulfo-Cyanine5 tetrazine

Water soluble Cyanine dye tetrazine derivative for TCO ligation with trans-cyclooctenes and other strained olefines.
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Cat. # Quantity Price Lead time
133E0 1 mg $125 in stock
233E0 5 mg $325 in stock
333E0 10 mg $470 in stock
433E0 25 mg $850 in stock
533E0 50 mg $1490 in stock
633E0 100 mg $1990 in stock
Found better price? Let us know and we will propose the way forward!

sulfo-Cyanine5.5 DBCO

Sulfo-Cyanine5.5 DBCO is a far-red, water-soluble reagent for copper-free click reaction with azides.
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Cat. # Quantity Price Lead time
173F0 1 mg $125 in stock
273F0 5 mg $325 in stock
473F0 25 mg $850 in stock
573F0 50 mg $1490 in stock
673F0 100 mg $1990 in stock
Found better price? Let us know and we will propose the way forward!

sulfo-Cyanine5.5 tetrazine

Tetrazine derivative of water-soluble far-red emitting fluorescent dye sulfo-Cyanine5.5 for TCO ligation with trans-cyclooctenes and other strained olefins.
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Cat. # Quantity Price Lead time
173E0 1 mg $125 in stock
273E0 5 mg $325 in stock
473E0 25 mg $850 in stock
573E0 50 mg $1490 in stock
673E0 100 mg $1990 in stock
Found better price? Let us know and we will propose the way forward!

sulfo-Cyanine7 DBCO

Dibenzocyclooctyne (DBCO, or ADIBO) conjugated with sulfo-Cyanine7, a water-soluble near-IR dye for labeling azide-containing biomolecules inside living cells, whole organisms, and inanimate samples.
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Cat. # Quantity Price Lead time
153F0 1 mg $125 in stock
253F0 5 mg $325 in stock
453F0 25 mg $850 in stock
553F0 50 mg $1490 in stock
653F0 100 mg $1990 in stock
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sulfo-Cyanine7 tetrazine

Near infrared, water soluble dye methyltetrazine for the conjugation with strained cycloalkenes in TCO ligation reaction.
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Cat. # Quantity Price Lead time
153E0 1 mg $125 in stock
253E0 5 mg $325 in stock
453E0 25 mg $850 in stock
553E0 50 mg $1490 in stock
653E0 100 mg $1990 in stock
Found better price? Let us know and we will propose the way forward!

TAMRA DBCO, 5-isomer

Cyclooctyne derivative of tetramethylrhodamine (TMR, TAMRA) for copper-free click chemistry conjugation with azides. Pure 5-isomer.
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Cat. # Quantity Price Lead time
171F0 1 mg $125 in stock
271F0 5 mg $395 in stock
471F0 25 mg $890 in stock
571F0 50 mg $1490 in stock
671F0 100 mg $1990 in stock
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TCO phosphoramidite C6

Trans-cyclooctene (TCO) amidite is used to introduce a TCO moiety into substrates containing primary or secondary hydroxyl group
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Cat. # Quantity Price Lead time
4017-100mg 100 mg $480 in stock
4017-250mg 250 mg $920 in stock
4017-1g 1 g please inquire in stock
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TCO-PEG4-NHS ester (axial isomer)

A heterobifunctional linker with trans-cyclooctene and NHS ester groups flanking PEG4 (tetraethylene glycol) for labeling of antibodies, proteins, and other primary amine-containing biomolecules.
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Cat. # Quantity Price Lead time
3056-10mg 10 mg $145 in stock
3056-25mg 25 mg $225 in stock
3056-100mg 100 mg $550 in stock
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VdU (5-Vinyl-2'-deoxyuridine)

VdU is a synthetic analog of thymidine for studying de novo DNA synthesis and cell proliferation.
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Cat. # Quantity Price Lead time
D2540 25 mg $225 in stock
F2540 100 mg $785 in stock
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VU (5-Vinyl-uridine)

Uridine derivative with a terminal alkene group for monitoring and investigating cell RNA transcription.
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Cat. # Quantity Price Lead time
3517-10mg 10 mg $125 in stock
3517-50mg 50 mg $449 in stock
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