Cycloalkenes in Reactive groups

Cycloalkenes are strained alkenes, tetrazine-reactive derivatives for inverse electron-demand Diels-Alder cycloaddition reaction (IEDDA).

Trans-cyclooctene (TCO) is one of the most used cycloalkenes for bioconjugation tasks. TCO-Tetrazine ligation possesses ultrafast kinetics, selectivity, high yielding, and long-term aqueous stability, which is important in low-concentration applications such as protein-protein conjugations, etc.

AF 488 TCO

AF 488-containing derivative of trans-cyclooctene (TCO) for conjugation with tetrazine via the inverse electron-demand Diels-Alder cycloaddition reaction (IEDDA).
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Cat. # Quantity Price Lead time
118H0 1 mg $199 in stock
218H0 5 mg $649 in stock
418H0 25 mg $1789 in stock
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TCO phosphoramidite C6

Trans-cyclooctene (TCO) amidite is used to introduce a TCO moiety into substrates containing primary or secondary hydroxyl group
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Cat. # Quantity Price Lead time
4017-100mg 100 mg $480 in stock
4017-250mg 250 mg $920 in stock
4017-1g 1 g please inquire in stock
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TCO-PEG4-NHS ester (axial isomer)

A heterobifunctional linker with trans-cyclooctene and NHS ester groups flanking PEG4 (tetraethylene glycol) for labeling of antibodies, proteins, and other primary amine-containing biomolecules.
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Cat. # Quantity Price Lead time
3056-10mg 10 mg $145 in stock
3056-25mg 25 mg $225 in stock
3056-100mg 100 mg $550 in stock
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