sulfo-Cyanine5 tetrazine

Tetrazines Copper-free click chemistry sulfo-Cyanine5
Cat. # Quantity Price Lead time
133E0 1 mg $125 in stock
233E0 5 mg $325 in stock
333E0 10 mg $470 in stock
433E0 25 mg $850 in stock
533E0 50 mg $1490 in stock
633E0 100 mg $1990 in stock
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TCO (tetrazine – trans-cyclooctene) ligation is one of the fastest reactions used for bioconjugation. It is an inverse electron demand [4+2] cycloaddition that takes place between tetrazine and trans-cyclooctene or other strained olefins.

sulfo-Cyanine5 tetrazine is a fluorophore derivative bearing a tetrazine group for the TCO-ligation-based labeling.

This reagent possesses good aqueous solubility and stability in biological environments.

Sulfo-Cyanine5 tetrazine, 333E0
Sulfo-Cyanine5 tetrazine, 333E0
Sulfo-Cyanine5 tetrazine, 333E0
Sulfo-Cyanine5 tetrazine structure
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Absorption and emission spectra of Sulfo-Cyanine5

Absorption and emission spectra of Sulfo-Cyanine5

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General properties

Appearance: dark blue solid
Molecular weight: 864.09
Molecular formula: C42H46KN7O7S2
Solubility: good in water, DMF, DMSO
Quality control: NMR 1H, HPLC-MS (95%)
Storage conditions: Storage: 24 months after receival at -20°C in the dark. Transportation: at room temperature for up to 3 weeks. Avoid prolonged exposure to light. Desiccate.
MSDS: Download
Product specifications

Spectral properties

Excitation/absorption maximum, nm: 646
ε, L⋅mol−1⋅cm−1: 271000
Emission maximum, nm: 662
Fluorescence quantum yield: 0.28
CF260: 0.04
CF280: 0.04

Product citations

  1. Comeo, E.; Goulding, J.; Lin, C.-Y.; Groenen, M.; Woolard, J.; Kindon, N. D.; Harwood, C. R.; Platt, S.; Briddon, S. J.; Kilpatrick, L. E.; Scammells, P. J.; Hill, S. J.; Kellam, B. Ligand-Directed Labeling of the Adenosine A1 Receptor in Living Cells. J. Med. Chem., 2024, 67(14), 12099–12117. doi: 10.1021/acs.jmedchem.4c00835
  2. Kerr, M. D.; McBride, D. A.; Johnson, W. T.; Chumber, A. K.; Najibi, A. J.; Seo, B. R.; Stafford, A. G.; Scadden, D. T.; Mooney, D. J.; Shah, N. J. Immune-Responsive Biodegradable Scaffolds for Enhancing Neutrophil Regeneration. Bioengineering & Translational Medicine, 2023, 8(1), e10309. doi: 10.1002/btm2.10309
  3. Kerr, M.D.; Johnson, W.T.; McBride, D.A.; Chumber, A.K.; Shah, N.J. Biodegradable scaffolds for enhancing vaccine delivery. Bioengineering & translational medicine, 2023, 8(6), e10591. doi: 10.1002/btm2.10591
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