Thalidomide-O-PEG2-carboxylic acid

Carboxylic acids PROTAC Crosslinking

Cat. #	Quantity	Price	Lead time	Buy this product
4192-25mg	25 mg	$145	in stock
4192-100mg	100 mg	$425	in stock

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Thalidomide-containing building block with PEG2-linker and carboxylic group for convenient PROTAC molecule assembly via conjugation with amino-functionalized linkers and target protein ligands. The carboxylic acid functional group should be activated with peptide coupling reagents like PyBOP or carbodiimides like EDC to form a stable amide linkage with amines. PEG2 is a hydrophilic linker providing a good separation between the parts of the PROTAC molecule.

Proteolysis targeting chimeras (PROTACs) are cell-permeable heterobifunctional molecules that can remove specific proteins from the cell. One end of such molecule contains a ligand to bind to the target, and the second end recruits the E3 ligase complex. Close proximity results in substrate polyubiquitination and subsequent protein degradation by cellular proteasome.

There are several types of E3 ligases that are practically suitable for such a purpose. Thalidomide is the ligand capable of recruiting Cereblon (CRBN) E3 ligase.

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General properties

Appearance:	off-white solid
Molecular weight:	434.40
Molecular formula:	C₂₀H₂₂N₂O₉
Solubility:	in DMSO, DMF
Quality control:	NMR ¹H and HPLC-MS (95+%)
Storage conditions:	24 months after receival at -20°C in the dark. Transportation: at room temperature for up to 3 weeks. Desiccate.
MSDS:	Download
	Product specifications

Product is offered and sold for research purposes only. Product is not tested for safety and efficacy in food, drug, medical device, cosmetic, no express or implied authorization to use for any other purpose, including, without limitation, in vitro diagnostic purposes, for humans or animals or for commercial purposes.

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