VHL Ligand 1 dihydrochloride
Cat. # | Quantity | Price | Lead time | Buy this product |
---|---|---|---|---|
4065-250mg | 250 mg | $175 | in stock | |
4065-500mg | 500 mg | $258 | in stock | |
4065-1g | 1 g | $469 | in stock |
Proteolysis targeting chimeras (PROTACs) are cell-permeable heterobifunctional molecules that can remove specific proteins from the cell. One end of such molecule contains a ligand to bind to the target, and the second end recruits the E3 ligase complex. Close proximity results in substrate polyubiquitination and subsequent protein degradation by cellular proteasome.
VHL Ligand 1 (VH032-NH2, (S,R,S)-AHPC) is a synthetic E3 ligase ligand that is used as a building block for the synthesis of proteolysis-targeting chimera (PROTAC) molecules.
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(S,R,S)-AHPC-PEG2-C2-azide
Degrader building block containing an E3 ligase ligand with linker and azide group, which can be conjugated to alkyne-functionalized linkers and target protein ligands through click chemistry reactions.General properties
Appearance: | yellow-brown powder |
Molecular weight: | 503.50 |
CAS number: | 1448189-80-7 (monohydrochloride) |
Molecular formula: | C22H32Cl2N4O3S |
IUPAC name: | (4R)-3-methyl-L-valyl-4-hydroxy-N-[[4-(4-methyl-5-thiazolyl)phenyl]methyl]-L-prolinamide, dihydrochloride |
Solubility: | methanol, DCM, DMF, DMSO |
Quality control: | NMR 1H and HPLC-MS (95+%) |
Storage conditions: | 24 months after receival at -20°C in the dark. Transportation: at room temperature for up to 3 weeks. Desiccate. |
MSDS: | Download |
Product specifications |