VHL Ligand 1 dihydrochloride

Cat. # Quantity Price Lead time
4065-250mg 250 mg $175 in stock
4065-500mg 500 mg $258 in stock
4065-1g 1 g $469 in stock
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Proteolysis targeting chimeras (PROTACs) are cell-permeable heterobifunctional molecules that can remove specific proteins from the cell. One end of such molecule contains a ligand to bind to the target, and the second end recruits the E3 ligase complex. Close proximity results in substrate polyubiquitination and subsequent protein degradation by cellular proteasome.

VHL Ligand 1 (VH032-NH2, (S,R,S)-AHPC) is a synthetic E3 ligase ligand that is used as a building block for the synthesis of proteolysis-targeting chimera (PROTAC) molecules.

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(S,R,S)-AHPC-PEG2-C2-azide

Degrader building block containing an E3 ligase ligand with linker and azide group, which can be conjugated to alkyne-functionalized linkers and target protein ligands through click chemistry reactions.

General properties

Appearance: yellow-brown powder
Molecular weight: 503.50
CAS number: 1448189-80-7 (monohydrochloride)
Molecular formula: C22H32Cl2N4O3S
IUPAC name: (4R)-3-methyl-L-valyl-4-hydroxy-N-[[4-(4-methyl-5-thiazolyl)phenyl]methyl]-L-prolinamide, dihydrochloride
Solubility: methanol, DCM, DMF, DMSO
Quality control: NMR 1H and HPLC-MS (95+%)
Storage conditions: 24 months after receival at -20°C in the dark. Transportation: at room temperature for up to 3 weeks. Desiccate.
MSDS: Download
Product specifications
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