(S,R,S)-AHPC-PEG2-C2-azide

Cat. # Quantity Price Lead time
4530-25mg 25 mg $189 in stock
4530-100mg 100 mg $529 in stock
4530-500mg 500 mg $1598 in stock
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Proteolysis targeting chimeras (PROTACs) are cell-permeable heterobifunctional molecules that can remove specific proteins from the cell. One end of such molecule contains a ligand to bind to the target, and the second end recruits the E3 ligase complex. Close proximity results in substrate polyubiquitination and subsequent protein degradation by cellular proteasome.

(S,R,S)-AHPC-C2-azide is a protein degrader building block for the synthesis of molecules for targeted protein degradation and PROTAC technologies. This conjugate contains a von Hippel-Lindau (VHL)-recruiting ligand and a PEG2-C2 crosslinker with an azide function group, which can be conjugated to alkyne-functionalized linkers and target protein ligands through click chemistry reactions.

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Thalidomide-O-PEG2-carboxylic acid

Thalidomide-containing building block with PEG2-linker and carboxylic group for conjugation with amino-functionalized linkers and target protein ligands.
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Thalidomide-carboxylic acid

Thalidomide-containing building block with carboxylic acid functionality for convenient PROTAC molecule assembly by attachment amino-functionalized linkers and ligands to thalidomide via 4-O-position.

General properties

Appearance: yellow glassy oil
Molecular weight: 615.75
CAS number: 2597167-22-9
Molecular formula: C29H41N7O6S
Solubility: methanol, ethyl acetate, DCM, THF, DMF, DMSO
Quality control: NMR 1H and HPLC-MS (95+%)
Storage conditions: 24 months after receival at -20°C in the dark. Transportation: at room temperature for up to 3 weeks. Desiccate.
MSDS: Download
Product specifications
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