(S,R,S)-AHPC-PEG2-C2-azide
Cat. # | Quantity | Price | Lead time | Buy this product |
---|---|---|---|---|
4530-25mg | 25 mg | $189 | in stock | |
4530-100mg | 100 mg | $529 | in stock | |
4530-500mg | 500 mg | $1598 | in stock |
Proteolysis targeting chimeras (PROTACs) are cell-permeable heterobifunctional molecules that can remove specific proteins from the cell. One end of such molecule contains a ligand to bind to the target, and the second end recruits the E3 ligase complex. Close proximity results in substrate polyubiquitination and subsequent protein degradation by cellular proteasome.
(S,R,S)-AHPC-C2-azide is a protein degrader building block for the synthesis of molecules for targeted protein degradation and PROTAC technologies. This conjugate contains a von Hippel-Lindau (VHL)-recruiting ligand and a PEG2-C2 crosslinker with an azide function group, which can be conjugated to alkyne-functionalized linkers and target protein ligands through click chemistry reactions.
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Thalidomide-containing building block with carboxylic acid functionality for convenient PROTAC molecule assembly by attachment amino-functionalized linkers and ligands to thalidomide via 4-O-position.Thalidomide-O-PEG2-carboxylic acid
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General properties
Appearance: | yellow glassy oil |
Molecular weight: | 615.75 |
CAS number: | 2597167-22-9 |
Molecular formula: | C29H41N7O6S |
Solubility: | methanol, ethyl acetate, DCM, THF, DMF, DMSO |
Quality control: | NMR 1H and HPLC-MS (95+%) |
Storage conditions: | 24 months after receival at -20°C in the dark. Transportation: at room temperature for up to 3 weeks. Desiccate. |
MSDS: | Download |
Product specifications |