(S,R,S)-AHPC-PEG2-C2-amine

PROTAC Amines

Cat. #	Quantity	Price	Lead time
4537-25mg	25 mg	$189	in stock
4537-100mg	100 mg	$489	in stock
4537-500mg	500 mg	$1880	in stock

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Proteolysis targeting chimeras (PROTACs) are cell-permeable heterobifunctional molecules that can remove specific proteins from the cell. One end of such molecule contains a ligand to bind to the target, and the second end recruits the E3 ligase complex. Close proximity results in substrate polyubiquitination and subsequent protein degradation by cellular proteasome.

(S,R,S)-AHPC-C2-amine is a protein degrader building block for synthesizing molecules for targeted protein degradation and PROTAC technologies. This conjugate contains a von Hippel-Lindau (VHL)-recruiting ligand and a PEG2-C2 crosslinker with an amine function group, which can be conjugated to other functionalized linkers and target protein ligands.

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Thalidomide-containing building block with PEG2-linker and amino group for conjugation with other functionalized linkers and target protein ligands.

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(S,R,S)-AHPC-PEG2-C2-azide

Degrader building block containing an E3 ligase ligand with linker and azide group, which can be conjugated to alkyne-functionalized linkers and target protein ligands through click chemistry reactions.

General properties

Appearance:	beige powder
Molecular weight:	626.21
CAS number:	2138439-54-8
Molecular formula:	C₂₉H₄₄ClN₅O₆S
Solubility:	methanol, ethyl acetate, DCM, THF, DMF, DMSO
Quality control:	NMR ¹H and HPLC-MS (95+%)
Storage conditions:	24 months after receival at -20°C in the dark. Transportation: at room temperature for up to 3 weeks. Desiccate.
MSDS:	Download
	Product specifications

This Product is offered and sold for research purposes only. It has not been tested for safety and efficacy in food, drug, medical device, cosmetic, commercial or any other use. Supply does not express or imply authorization to use for any other purpose, including, without limitation, in vitro diagnostic purposes, in the manufacture of food or pharmaceutical products, in medical devices or in cosmetic products.

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