Biotin phosphoramidite (hydroxyprolinol)

Biotinylation Phosphoramidites
Cat. # Quantity Price Lead time
22360 250 mg $240 in stock
42360 1 g $760 in stock
62360 5 g $3040 in stock
82360 10 g please inquire in stock
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Non-nucleosidic modifier reagent for the synthesis of biotinylated oligos based on a hydroxyprolinol core. This phosphoramidite contains a dimethoxytrityl protective group for the purification of the resulting oligos on C18 cartridges, and reverse phase HPLC. This modifier reagent can be used to introduce biotin onto 5'-position, 3'-position (using universal CPG), and internal oligo sites.

This amidite does not require special condensation and deprotection conditions.

Biotin phosphoramidite (hydroxyprolinol)
Biotin phosphoramidite (hydroxyprolinol)
Biotin phosphoramidite (hydroxyprolinol)
Structure of biotin phosphoramidite
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General properties

Appearance: white powder
Molecular weight: 959.18
Molecular formula: C51H71N6O8PS
Solubility: good in MeCN, DCM, THF
Quality control: NMR 1H, 31P, HPLC-MS (95%), functional testing in oligo synthesis
Storage conditions: Storage: 12 months after receival at -20°C in the dark. Transportation: at room temperature for up to 3 weeks. Desiccate.
MSDS: Download
Product specifications

Oligo synthesis details

Diluent: acetonitrile
Coupling conditions: standard coupling, identical to normal nucleobases
Deprotection conditions: identical to protected nucleobases
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