DBCO-maleimide
Cat. # | Quantity | Price | Lead time | Buy this product |
---|---|---|---|---|
4448-100mg | 100 mg | $319 | in stock | |
4448-500mg | 500 mg | $1028 | in stock |
DBCO-maleimide is a bifunctional linker containing a maleimide group and a DBCO (Dibenzocyclooctyne, ADIBO) moiety.
The maleimide group specifically and efficiently reacts with thiols to form thioether bonds. The low mass weight adds minimal spacer to modified molecules and enables the simple and efficient incorporation of the DBCO moiety into cysteine-containing peptides or other thiol-containing biomolecules.
DBCO is one of the most reactive cycloalkynes for strain-promoted alkyne azide cycloaddition (SPAAC). DBCO reacts instantly with azides without needing a Cu(I) catalyst, resulting in a stable triazole linkage. The reaction rate is much higher than that of copper-catalyzed reaction, and reactions with many other cyclooctynes. Unlike other cyclooctynes, DBCO does not react with tetrazines — this allows to carry out orthogonal conjugation of azides with DBCO and trans-cyclooctenes with tetrazines.
Recommended protocol
Calculator
Customers also purchased with this product
DBCO-STP ester
Activated ester for modification of proteins/antibodies/peptides followed by introduction into copper-free click chemistry reaction.get free express delivery
3-Maleimidopropionic acid NHS-ester
Bifunctional crosslinker with an amine-reactive succinimidyl ester and a thiol-reactive maleimide group.DBCO-NHS ester
Azodibenzocyclooctyne (DBCO, ADIBO) reagent for strain-promoted copper-free click chemistry (SPAAC). The reagent contains an NHS ester function for the attachment of the cyclooctyne to various molecules.General properties
Appearance: | white solid |
Molecular weight: | 441.49 |
Molecular formula: | C26H23N3O4 |
Solubility: | methylene, DMSO, DMF, acetonitrile |
Quality control: | NMR 1H and HPLC-MS (95+%) |
Storage conditions: | 12 months after receival at -20°C in the dark. Transportation: at room temperature for up to 3 weeks. Desiccate. |
MSDS: | Download |
Product specifications |