DMS(O)MT aminolink C6
| Cat. # | Quantity | Price | Lead time | Buy this product |
|---|---|---|---|---|
| 23260 | 250 mg | $140 | in stock | |
| 43260 | 1 g | $350 | in stock | |
| 63260 | 5 g |
$1280
|
in stock | |
| 83260 | 10 g |
$2540
|
in stock | |
| 93260 | 25 g | please inquire | in stock |
Aminolink phosphoramidite for oligonucleotide synthesis. DMS(O)MT is a special protective group similar to traditional MMT, but designed as an improved alternative to it. DMS(O)MT aminolink is fully compatible with standard coupling, deblock, and purification protocols. However, DMS(O)MT group is much better suited for DMT-on and cartridge purification of amino-oligonucleotides because of higher stability, and better oligonucleotide recovery. Oligonucleotides containing DMS(O)MT are more stable in solution than MMT analogs.
In case of cartridge purification, DMS(O)MT protection allows for 2-3 fold increase of oligonucleotide yield, making this reagent a unique solution for high-throughput manufacturing of amino-oligonucleotides.
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Amine-reactive Cyanine5 activated ester for the labeling of proteins, peptides, and other molecules.Universal CPG type II, 1000A
This universal support is intended for automated synthesis of oligonucleotides to accelerate the dephosphorylation process during deblocking. Pore size of 1000 Å is recommended for the synthesis of oligonucleotides up to 120 bases.Biotin (hydroxyprolinol) CPG 1000
Solid-phase support based on hydroxyprolinol for the synthesis of oligonucleotides containing biotin at the 3' terminus.General properties
| Appearance: | yellowish viscous oil |
| Molecular weight: | 681.86 |
| CAS number: | 1173109-53-9 |
| Molecular formula: | C37H52N3O5PS |
| Solubility: | soluble in acetonitrile, dichloromethane |
| Quality control: | NMR 1H, 31P, HPLC (95%) |
| Storage conditions: | Storage: 12 months after receival at -20°C in the dark. Transportation: at room temperature for up to 3 weeks. |
| MSDS: | Download |
| Product specifications |
Oligo synthesis details
| Diluent: | acetonitrile |
| Coupling conditions: | standard coupling, identical to normal nucleobases |
| Cleavage conditions: | ammonia, 2 h at room temperature; if an oligonucleotide with trityl group needs to be evaporated, add small amount of Tris base before it, or trityl group can be lost. |
| Deprotection conditions: | identical to protected nucleobases. Trityl group can be removed by acidic cleavage in either 80% acetic acid, or on C18 cartridge during purification using 2% to 4% trifluoroacetic acid. |
Product citations
- Novopashina, D.; Vorobyeva, M.; Nazarov, A.; Davydova, A.; Danilin, N.; Koroleva, L.; Matveev, A.; Bardasheva, A.; Tikunova, N.; Kupryushkin, M.; Pyshnyi, D.; Altman, S.; Venyaminova, A. Novel Peptide Conjugates of Modified Oligonucleotides for Inhibition of Bacterial RNase P. Frontiers in Pharmacology, 2019, 10, 813. doi: 10.3389/fphar.2019.00813
- Aparin, I.O.; Farzan, V.M.; Veselova, O.A.; Chistov, A.A.; Podkolzin, A.T.; Ustinov, A.V.; Shipulin, G.A.; Formanovsky, A.A.; Korshun, V.A.; Zatsepin, T.S. 1-Phenylethynylpyrene (PEPy) as a novel blue-emitting dye for qPCR assay. Analyst, 2016, 141, 1331–1338. doi: 10.1039/c5an01767j
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