TCO-PEG4-NHS ester (axial isomer)

NHS esters Copper-free click chemistry Protein labeling Cycloalkenes Crosslinking
Cat. # Quantity Price Lead time
3056-10mg 10 mg $145 in stock
3056-25mg 25 mg $225 in stock
3056-100mg 100 mg $550 in stock
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TCO-PEG4-NHS ester is a bifunctional linker with trans-cyclooctene (TCO) and NHS ester groups flanking PEG4 (tetraethylene glycol).

The PEG spacer increases solubility in aqueous media and provides a long and flexible connection that minimizes steric hindrance involved with ligation.

The amine-reactive N-hydroxysuccinimide residue provides easy attachment to almost any primary or secondary amine group, such as protein, peptide, or small molecule amine.

Trans-cyclooctene readily reacts with tetrazines via inverse electron-demand Diels-Alder cycloaddition (IEDDA). TCO-Tetrazine ligation possesses ultrafast kinetics, selectivity, and long-term aqueous stability, which is important in low-concentration applications such as protein-protein conjugations, etc.

TCO-PEG4-NHS ester (axial isomer), 3056-100mg
TCO-PEG4-NHS ester (axial isomer), 3056-100mg
TCO-PEG4-NHS ester (axial isomer), 3056-100mg
Structure of TCO-PEG4-NHS ester
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General properties

Appearance: colorless syrup
Molecular weight: 514.57
CAS number: 1621096-79-4
Molecular formula: C24H38N2O10
Solubility: DMSO, DMF, THF, DCM, Acetonitrile
Quality control: NMR 1H and HPLC-MS (95+%)
Storage conditions: 12 months after receival at -20°C in the dark. Transportation: at room temperature for up to 3 weeks. Desiccate.
MSDS: Download
Product specifications
This Product is offered and sold for research purposes only. It has not been tested for safety and efficacy in food, drug, medical device, cosmetic, commercial or any other use. Supply does not express or imply authorization to use for any other purpose, including, without limitation, in vitro diagnostic purposes, in the manufacture of food or pharmaceutical products, in medical devices or in cosmetic products.
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