TCO-PEG4-NHS ester (axial isomer)

Cat. # Quantity Price Lead time
3056-10mg 10 mg $145 in stock
3056-25mg 25 mg $225 in stock
3056-100mg 100 mg $550 in stock
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TCO-PEG4-NHS ester is a bifunctional linker with trans-cyclooctene (TCO) and NHS ester groups flanking PEG4 (tetraethylene glycol).

The PEG spacer increases solubility in aqueous media and provides a long and flexible connection that minimizes steric hindrance involved with ligation.

The amine-reactive N-hydroxysuccinimide residue provides easy attachment to almost any primary or secondary amine group, such as protein, peptide, or small molecule amine.

Trans-cyclooctene readily reacts with tetrazines via inverse electron-demand Diels-Alder cycloaddition (IEDDA). TCO-Tetrazine ligation possesses ultrafast kinetics, selectivity, and long-term aqueous stability, which is important in low-concentration applications such as protein-protein conjugations, etc.

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General properties

Appearance: colorless syrup
Molecular weight: 514.57
CAS number: 1621096-79-4
Molecular formula: C24H38N2O10
Solubility: DMSO, DMF, THF, Acetonitrile, Dichloromethane
Quality control: NMR 1H and HPLC-MS (95+%)
Storage conditions: 12 months after receival at -20°C in the dark. Transportation: at room temperature for up to 3 weeks. Desiccate.
MSDS: Download
Product specifications
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