AF 488 TCO
Cat. # | Quantity | Price | Lead time | Buy this product |
---|---|---|---|---|
118H0 | 1 mg | $199 | in stock | |
218H0 | 5 mg | $649 | in stock | |
418H0 | 25 mg | $1789 | in stock |
Trans-cyclooctene (TCO) is one of the most used cycloalkenes for bioconjugation tasks. TCO readily reacts with tetrazines via inverse electron-demand Diels-Alder cycloaddition (IEDDA). TCO-Tetrazine ligation possesses ultrafast kinetics, selectivity, and long-term aqueous stability, which is important in low-concentration applications such as protein-protein conjugations, etc.
This TCO is a AF 488-containing derivative. AF 488 is sulfonated rhodamine, a bright, photostable, and hydrophilic fluorophore that emits in the green channel. The absorption maximum is 495 nm. The emission maximum is 519 nm.
Absorption and emission spectra of AF 488
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Dibenzocyclooctyne (DBCO, ADIBO) containing the orange fluorophore AF 568 for cooper-free labeling azide-tagged biomolecules inside live cells, whole organisms, and inanimate samples.General properties
Appearance: | orange powder |
Molecular weight: | 989.27 |
Molecular formula: | C48H70N6O12S2 |
Solubility: | good in water, DMSO; moderate in acetonitrile |
Quality control: | NMR 1H and HPLC-MS (95+%) |
Storage conditions: | 24 months after receival at -20°C in the dark. Transportation: at room temperature for up to 3 weeks. Desiccate. Avoid prolonged exposure to light. |
MSDS: | Download |
Product specifications |
Spectral properties
Excitation/absorption maximum, nm: | 495 |
ε, L⋅mol−1⋅cm−1: | 71800 |
Emission maximum, nm: | 519 |
Fluorescence quantum yield: | 0.91 |
CF260: | 0.16 |
CF280: | 0.10 |