Alkyne amidite, hydroxyprolinol

Oligonucleotide synthesis Alkynes Phosphoramidites Click chemistry

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Phosphoramidite for the synthesis of alkyne-modified oligonucleotides. Oligonucleotides can be used for сlick сhemistry modification (see the protocol).

Diluent for this amidite is acetonitrile, 5 min coupling time is recommended. Standard deprotection conditions can be used for oligonucleotides.

Oligonucleotides can be purified by HPLC or cartridges due to the presence of dimethoxytrityl group, as well as by PAGE.

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General properties

Appearance:	colorless semisolid
Molecular weight:	713.84
CAS number:	1357289-02-1
Molecular formula:	C₄₁H₅₂N₃O₆P
IUPAC name:	Phosphoramidous acid, N,N-bis(1-methylethyl)-, (3R,5S)-5-[[bis(4-methoxyphenyl)phenylmethoxy]methyl]-1-(1-oxo-5-hexyn-1-yl)-3-pyrrolidinyl 2-cyanoethyl ester
Solubility:	good in acetonitrile and dichloromethane
Quality control:	NMR ¹H and ³¹P, HPLC-MS (95 %)
Storage conditions:	Storage: 12 months after receival at -20°C. Transportation: at room temperature for up to 3 weeks. Desiccate.
MSDS:	Download
	Product specifications

Oligo synthesis details

Diluent:	acetonitrile
Coupling conditions:	standard coupling, identical to normal nucleobases
Deprotection conditions:	identical to protected nucleobases

This Product is offered and sold for research purposes only. It has not been tested for safety and efficacy in food, drug, medical device, cosmetic, commercial or any other use. Supply does not express or imply authorization to use for any other purpose, including, without limitation, in vitro diagnostic purposes, in the manufacture of food or pharmaceutical products, in medical devices or in cosmetic products.