Alkyne CPG modifier 500

Alkynes CPG modifier solid supports Oligonucleotide synthesis Click chemistry
Cat. # Quantity Price Lead time
12860 100 mg $60 in stock
22860 250 mg $120 in stock
32860 500 mg $230 in stock
42860 1 g $380 in stock
52860 5 g $1450 in stock
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High loading controlled pore glass solid support for the synthesis of oligonucleotides with 3'-alkyne group. With this solid support, synthesis of oligos of up to 50 bases is possible.

Terminal alkyne group can be modified by copper catalyzed Click chemistry (see our recommended protocol for oligonucleotide modification).

This solid support is compatible with standard oligonucleotide deblocking conditions. No special deblocking is required.

Alkyne CPG modifier 500, 52860
Alkyne CPG modifier 500, 52860
Alkyne CPG modifier 500, 52860
Alkyne CPG modifier controlled pore glass structure
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SIMA azide, 6-isomer

Azide of green-yellow emitting dye SIMA for conjugation with oligonucleotides via [3+2]-dipolar cycloaddition.

General properties

Appearance: off-white beads
Quality control: NMR 1H and HPLC (95%) of bound reagent, loading measurement
Storage conditions: Storage: 24 months after receival at -20°C. Transportation: at room temperature for up to 3 weeks. Desiccate.
MSDS: Download
Product specifications

Oligo synthesis details

Pore size, Å: 500
Typical loading, umol/g: 70−90
Coupling conditions: standard coupling, identical to normal nucleobases
Cleavage conditions: ammonia, 2 h at room temperature
Deprotection conditions: identical to protected nucleobases

Product citations

  1. Kolganova, N.A.; Tsvetkov, V.B.; Stomakhin, A.A.; Surzhikov, S.A.; Timofeev, E.N.; Varizhuk, I.V. Alpha-Deoxyguanosine to Reshape the Alpha-Thrombin Binding Aptamer. International Journal of Molecular Sciences, 2023, 24(9), 8406. doi: 10.3390/ijms24098406
  2. Petrunina, N.A.; Lebedev, V.V.; Kirillova, Y.G.; Aralov, A..V.; Varizhuk, A.M.; Sardushkin, M.V. DNA Intercalated Motifs with Non-Nucleoside Inserts. Russian Journal of Bioorganic Chemistry, 2021, 47(6), 1341–1344. doi: 10.1134/S1068162021060212
  3. Svetlova, J.; Sardushkin, M.; Kolganova, N.; Timofeev, E. Recognition Interface of the Thrombin Binding Aptamer Requires Antiparallel Topology of the Quadruplex Core. Biomolecules, 2021, 11(9), 1332. doi: 10.3390/biom11091332
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