sulfo-Cyanine5 tetrazine
| Cat. # | Quantity | Price | Lead time | Buy this product |
|---|---|---|---|---|
| 133E0 | 1 mg | $125 | in stock | |
| 233E0 | 5 mg | $325 | in stock | |
| 333E0 | 10 mg |
$470
|
in stock | |
| 433E0 | 25 mg |
$850
|
in stock | |
| 533E0 | 50 mg |
$1490
|
in stock | |
| 633E0 | 100 mg |
$1990
|
in stock |
TCO (tetrazine – trans-cyclooctene) ligation is one of the fastest reactions used for bioconjugation. It is an inverse electron demand [4+2] cycloaddition that takes place between tetrazine and trans-cyclooctene or other strained olefins.
sulfo-Cyanine5 tetrazine is a fluorophore derivative bearing a tetrazine group for the TCO-ligation-based labeling.
This reagent possesses good aqueous solubility and stability in biological environments.
Absorption and emission spectra of Sulfo-Cyanine5
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| Appearance: | dark blue solid |
| Molecular weight: | 864.09 |
| Molecular formula: | C42H46KN7O7S2 |
| Solubility: | good in water, DMF, DMSO |
| Quality control: | NMR 1H, HPLC-MS (95%) |
| Storage conditions: | Storage: 24 months after receival at -20°C in the dark. Transportation: at room temperature for up to 3 weeks. Avoid prolonged exposure to light. Desiccate. |
| MSDS: | Download |
| Product specifications |
Spectral properties
| Excitation/absorption maximum, nm: | 646 |
| ε, L⋅mol−1⋅cm−1: | 271000 |
| Emission maximum, nm: | 662 |
| Fluorescence quantum yield: | 0.28 |
| CF260: | 0.04 |
| CF280: | 0.04 |
Product citations
- Comeo, E.; Goulding, J.; Lin, C.-Y.; Groenen, M.; Woolard, J.; Kindon, N. D.; Harwood, C. R.; Platt, S.; Briddon, S. J.; Kilpatrick, L. E.; Scammells, P. J.; Hill, S. J.; Kellam, B. Ligand-Directed Labeling of the Adenosine A1 Receptor in Living Cells. J. Med. Chem., 2024, 67(14), 12099–12117. doi: 10.1021/acs.jmedchem.4c00835
- Kerr, M. D.; McBride, D. A.; Johnson, W. T.; Chumber, A. K.; Najibi, A. J.; Seo, B. R.; Stafford, A. G.; Scadden, D. T.; Mooney, D. J.; Shah, N. J. Immune-Responsive Biodegradable Scaffolds for Enhancing Neutrophil Regeneration. Bioengineering & Translational Medicine, 2023, 8(1), e10309. doi: 10.1002/btm2.10309
- Kerr, M.D.; Johnson, W.T.; McBride, D.A.; Chumber, A.K.; Shah, N.J. Biodegradable scaffolds for enhancing vaccine delivery. Bioengineering & translational medicine, 2023, 8(6), e10591. doi: 10.1002/btm2.10591
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