Disuccinimidyl glutarate (DSG)

NHS esters Crosslinking

Cat. #	Quantity	Price	Lead time	Buy this product
4018-100mg	100 mg	$95	in stock
4018-1g	1 g	$410	in stock

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Items in stock will be shipped on 04/02/2025

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Disuccinimidyl glutarate (DSG) is a homobifunctional crosslinker that contains two N-hydroxysuccinimide (NHS) ester groups at each end of a short 5-atom (7.7 angstrom) spacer.

DSG is a membrane-permeable and non-cleavable crosslinker, allowing for intracellular labeling of peptides and proteins. NHS esters react with amines of lysine residues and N-termini of peptides and proteins, forming a covalent amide bond and releasing the NHS group. DSG is commonly used to pair radiolabelled ligands to cell surface receptors and determine DNA-protein binding interactions in ChIP assays. DSG labeling is often combined with formaldehyde fixation to improve the detection of DNA-protein complexes.

DSG is water-insoluble and must be dissolved in an organic solvent, such as DMSO or DMF, before being added to aqueous solutions.

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NHS Ester Labeling of Biomolecules Containing Primary Amino Groups

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General properties

Appearance:	off-white powder
Molecular weight:	326.26
CAS number:	79642-50-5
Molecular formula:	C₁₃H₁₄N₂O₈
IUPAC name:	Bis(2,5-dioxopyrrolidin-1-yl) Pentanedioate
Solubility:	DMF, DMSO
Quality control:	NMR ¹H and HPLC-MS (95+%)
Storage conditions:	12 months after receival at -20°C in the dark. Transportation: at room temperature for up to 3 weeks. Desiccate.
MSDS:	Download
	Product specifications

Product is offered and sold for research purposes only. Product is not tested for safety and efficacy in food, drug, medical device, cosmetic, no express or implied authorization to use for any other purpose, including, without limitation, in vitro diagnostic purposes, for humans or animals or for commercial purposes.