Cyanine5 DBCO

Cycloalkynes Copper-free click chemistry Cyanine5
Cat. # Quantity Price Lead time
A30F0 1 mg $125 in stock
B30F0 5 mg $260 in stock
C30F0 10 mg $325 in stock
D30F0 25 mg $510 in stock
E30F0 50 mg $895 in stock
F30F0 100 mg $1490 in stock
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A derivative of Cyanine5 red-emitting fluorophore possessing DBCO (dibenzocyclooctyne, also known as ADIBO, azodibenzocyclooctyne) group for copper free click chemistry.

Strained cycloalkynes, such as cyclooctynes, react with azides very rapidly in the absence of copper catalyst in a strain-promoted alkyne-azide cycloaddition (SPAAC). This reaction is very fast, mild, and biocompatible.

Compared to other cycloalkynes, DBCO provide among the fastest reaction kinetics, still possessing good stability.

Cyanine5 DBCO, C30F0
Cyanine5 DBCO, C30F0
Cyanine5 DBCO, C30F0
Structure of Cyanine5 DBCO
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Absorption and emission spectra of Cyanine5

Absorption and emission spectra of Cyanine5

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General properties

Appearance: dark blue solid
Mass spec M+ increment: 928.4
Molecular weight: 929.03
Molecular formula: C53H59N4F6O2P
Solubility: good in DMF, DMSO, chlorinated organic solvents, practically insoluble in water (<1 uM, < 1 mg/L)
Quality control: NMR 1H, HPLC-MS (95%)
Storage conditions: Storage: 12 months after receival at -20°C in the dark. Transportation: at room temperature for up to 3 weeks. Avoid prolonged exposure to light. Desiccate.
MSDS: Download
Product specifications

Spectral properties

Excitation/absorption maximum, nm: 646
ε, L⋅mol−1⋅cm−1: 250000
Emission maximum, nm: 662
Fluorescence quantum yield: 0.2

Product citations

  1. Toro-González, M.; Akingbesote, N.; Bible, A.; Sanders, B.; Ivanov, A.S.; Jansone-Popova, S.; Popovs, I.; Benny, P.; Perry, R.; Davern, S. Development of 225 Ac-doped Biocompatible Nanoparticles for Targeted Alpha Therapy. Research Square, 2024, preprint. doi: 10.21203/rs.3.rs-3921227/v1
  2. Wang, Y.-J.; Li, L.; Yu, J.; Hu, H.-Y.; Liu, Z.-X.; Jiang, W.-J.; Xu, W.; Guo, X.-P.; Wang, F.-S.; Sheng, J.-Z. Imaging of Escherichia Coli K5 and Glycosaminoglycan Precursors via Targeted Metabolic Labeling of Capsular Polysaccharides in Bacteria. Sci. Adv., 2023, 9(7), eade4770. doi: 10.1126/sciadv.ade4770
  3. Borner, T.; Tinsley, I. C.; Milliken, B. T.; Doebley, S. A.; Najjar, N. R.; Kerwood, D. J.; De Jonghe, B. C.; Hayes, M. R.; Doyle, R. P. Creation of a Peptide Antagonist of the GFRAL–RET Receptor Complex for the Treatment of GDF15-Induced Malaise. J. Med. Chem., 2023, 66(16), 11237–11249. doi: 10.1021/acs.jmedchem.3c00667
  4. Miranda, A.; Lopez-Blanco, R.; Lopes-Nunes, J.; Melo, A.M.; Campello, M.P.C.; Paulo, A.; Oliveira, M.C.; Mergny, J.-L.; Oliveira, P.A.; Fernandez-Megia, E.; Cruz, C. Gallic Acid–Triethylene Glycol Aptadendrimers Synthesis, Biophysical Characterization and Cellular Evaluation. Pharmaceutics, 2022, 14(11), 2456. doi: 10.3390/pharmaceutics14112456
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