FCCP, ATPase inhibitor
| Cat. # | Quantity | Price | Lead time | Buy this product |
|---|---|---|---|---|
| 4632-1mg | 1 mg | $25 | in stock | |
| 4632-10mg | 10 mg | $73 | in stock |
FCCP (trifluoromethoxy carbonylcyanide phenylhydrazone, carbonyl cyanide 4-(trifluoromethoxy)phenylhydrazone) is a proton (H+) ionophore and a potent mitochondrial uncoupling agent, which lowers ROS production and Ca2+ overload. This compound turns the mitochondrial membrane permeable to protons, thus dissipating the mitochondrial membrane potential and uncoupling oxidative phosphorylation from ATP synthesis.
FCCP is widely used to analyze mitochondrial function in living tissues, cells, and isolated mitochondrial preparations. It is also used to investigate the mechanisms of autophagy by inducing mitochondrial degradation through the disruption of the mitochondrial membrane potential.
A low concentration of FCCP (1 μM) results in a complete loss of mitochondrial membrane potential without triggering mitophagy, whereas a high concentration (10 μM) leads to increased cytosol acidification, and mitochondrial degradation is attained.
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| Appearance: | bright yellow crystals |
| Molecular weight: | 254.17 |
| CAS number: | 370-86-5 |
| Molecular formula: | C10H5F3N4O |
| IUPAC name: | 2-[2-[4-(trifluoromethoxy)phenyl]hydrazinylidene]-propanedinitrile |
| Solubility: | Soluble in DMSO (100 mM). Soluble in methanol, ethanol, and acetone to 20 mg/mL. Insoluble in water. |
| Quality control: | NMR 1H and HPLC-MS (95+%) |
| Storage conditions: | 24 months after receival at -20°C in the dark. Transportation: at room temperature for up to 3 weeks. Desiccate. |
| MSDS: | Download |
| Product specifications |
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