FCCP, ATPase inhibitor

Cat. # Quantity Price Lead time
4632-1mg 1 mg $25 in stock
4632-10mg 10 mg $73 in stock
Found better price? Let us know and we will propose the way forward!

FCCP (trifluoromethoxy carbonylcyanide phenylhydrazone, carbonyl cyanide 4-(trifluoromethoxy)phenylhydrazone) is a proton (H+) ionophore and a potent mitochondrial uncoupling agent, which lowers ROS production and Ca2+ overload. This compound turns the mitochondrial membrane permeable to protons, thus dissipating the mitochondrial membrane potential and uncoupling oxidative phosphorylation from ATP synthesis.

FCCP is widely used to analyze mitochondrial function in living tissues, cells, and isolated mitochondrial preparations. It is also used to investigate the mechanisms of autophagy by inducing mitochondrial degradation through the disruption of the mitochondrial membrane potential.

A low concentration of FCCP (1 μM) results in a complete loss of mitochondrial membrane potential without triggering mitophagy, whereas a high concentration (10 μM) leads to increased cytosol acidification, and mitochondrial degradation is attained.

Customers also purchased with this product

PO-TAP-3, yellow fluorescent nucleic acid stain

PO-TAP-3 is a cell-impermeant yellow fluorescent nucleic acid stain. PO-TAP-3 is chemically equivalent to PO-PRO®-3.

LumiTracker® Mito Red FM

Сell-permeant, cationic, red-fluorescent dye for staining active mitochondria in living cells in a potential-dependent manner.

LumiTracker Mito Orange CM-H2TMRos

A cationic, orange-fluorescent dye for staining active mitochondria in live cells. CM-H2TMRos is a reduced, nonfluorescent version of the CMTMRos dye that becomes fluorescent when oxidized at the mitochondrial membrane.

General properties

Appearance: bright yellow crystals
Molecular weight: 254.17
CAS number: 370-86-5
Molecular formula: C10H5F3N4O
IUPAC name: 2-[2-[4-(trifluoromethoxy)phenyl]hydrazinylidene]-propanedinitrile
Solubility: Soluble in DMSO (100 mM). Soluble in methanol, ethanol, and acetone to 20 mg/mL. Insoluble in water.
Quality control: NMR 1H and HPLC-MS (95+%)
Storage conditions: 24 months after receival at -20°C in the dark. Transportation: at room temperature for up to 3 weeks. Desiccate.
MSDS: Download
Product specifications
Your item has been added. View your cart or proceed to checkout
The count of items is incorrect.