AmdU (5-Azidomethyl-2'-deoxyuridine)

Azides Copper-free click chemistry

Cat. #	Quantity	Price	Lead time
B1540	5 mg	$120	in stock
D1540	25 mg	$255	in stock
F1540	100 mg	$890	in stock

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Azidomethyl-dU (AmdU) is a nucleoside that contains an azide group. The structure of the nucleoside is similar to thymidine, and it is incorporated into nascent DNA by cellular polymerases, similar to EdU.

In contrast to EdU which needs to be further modified with azides in the presence of the copper catalyst, AmdU can also react in the absence of copper catalyst using SPAAC click chemistry with strained cycloalkynes, such as cyclooctynes. This enables the detection of nascent DNA in benign, copper-free conditions.

Structure of AmdU (azidomethyldeoxyuridine)

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sulfo-Cyanine5 DBCO

Water-soluble cycloalkyne for copper-free click chemistry reaction with azides. A derivative of sulfo-Cyanine5.

THPTA ligand

THPTA is a water-soluble ligand for Cu(I)-catalyzed click chemistry. The ligand stabilizes copper in its Cu(I) oxidation state. Due to high aqueous solubility, reactions with this ligand do not require an organic co-solvent.

DBCO-STP ester

Activated ester for modification of proteins/antibodies/peptides followed by introduction into copper-free click chemistry reaction.

General properties

Appearance:	white / off white solid
Molecular weight:	283.24
CAS number:	59090-48-1
Molecular formula:	C₁₀H₁₃N₅O₅
IUPAC name:	5-Azidomethyl-2'-deoxyuridine
Solubility:	in water, alcohols, DMSO, DMF
Quality control:	NMR ¹H, HPLC-MS (95%)
Storage conditions:	Storage: 24 months after receival at -20°C in the dark. Transportation: at room temperature for up to 3 weeks. Avoid prolonged exposure to light. Desiccate.
MSDS:	Download
	Product specifications

Product is offered and sold for research purposes only. Product is not tested for safety and efficacy in food, drug, medical device, cosmetic, no express or implied authorization to use for any other purpose, including, without limitation, in vitro diagnostic purposes, for humans or animals or for commercial purposes.