Cyanine3-PEG4-BCN (exo)
This product is discontinued, and no longer available.
Cyanine3-PEG4-BCNcontains functional group bicyclononyne linked to a fluorophore Cyanine3. Bicyclo[6.1.0]nonyne (BCN) is a cyclooctyne with a significantly improved reactivity profile of strain-promoted azide-alkyne cycloaddition.
Conjugation of cyclooctyne constructs is used for labeling monoclonal antibodies containing an azido-functionalized amino acid with high conversion via copper-free click conjugation [1].
[1] Remon van Geel et al. Chemoenzymatic Conjugation of Toxic Payloads to the Globally Conserved N-Glycan of Native mAbs Provides Homogeneous and Highly Efficacious Antibody–Drug Conjugates. Bioconjugate Chemistry. 2015. 26(11). P.2233-2242.
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General properties
| Appearance: | dark red paste |
| Molecular weight: | 1014.79 |
| Molecular formula: | C58H84ClN5O8 |
| Quality control: | NMR 1H and HPLC-MS (95+%) |
| Storage conditions: | 24 months after receival at -20°C in the dark. Transportation: at room temperature for up to 3 weeks. Desiccate. Avoid prolonged exposure to light. |
| MSDS: | Download |
| Product specifications |
This Product is offered and sold for research purposes only. It has not been tested for safety and efficacy in food, drug, medical device, cosmetic, commercial or any other use. Supply does not express or imply authorization to use for any other purpose, including, without limitation, in vitro diagnostic purposes, in the manufacture of food or pharmaceutical products, in medical devices or in cosmetic products.
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