Cyanine3-PEG4-BCN (exo)

This product is discontinued, and no longer available.

Cyanine3-PEG4-BCNcontains functional group bicyclononyne linked to a fluorophore Cyanine3. Bicyclo[6.1.0]nonyne (BCN) is a cyclooctyne with a significantly improved reactivity profile of strain-promoted azide-alkyne cycloaddition.

Conjugation of cyclooctyne constructs is used for labeling monoclonal antibodies containing an azido-functionalized amino acid with high conversion via copper-free click conjugation [1].

[1] Remon van Geel et al. Chemoenzymatic Conjugation of Toxic Payloads to the Globally Conserved N-Glycan of Native mAbs Provides Homogeneous and Highly Efficacious Antibody–Drug Conjugates. Bioconjugate Chemistry. 2015. 26(11). P.2233-2242.

Customers also purchased with this product

Biotin-PEG4-NHS ester

PEG4-containing activated ester for simple and efficient biotin labeling of antibodies, proteins, and other primary amine-containing biomolecules.

AmdU (5-Azidomethyl-2'-deoxyuridine)

Azidomethyldeoxyuridine (AmdU) is an azide-contained nucleoside that is incorporated into nascent DNA by cellular polymerases. The azide groups attached to DNA this way can be subsequently modified with alkynes or cycloalkynes via copper-catalyzed or strain-promoted click reaction.

BDP® 558/568 alkyne

BDP 558/568 is a borondipyrromethene dye for Cyanine3-channel. This product is a terminal alkyne derivative for copper-catalyzed click chemistry.

General properties

Appearance: dark red paste
Molecular weight: 1014.79
Molecular formula: C58H84ClN5O8
Quality control: NMR 1H and HPLC-MS (95+%)
Storage conditions: 24 months after receival at -20°C in the dark. Transportation: at room temperature for up to 3 weeks. Desiccate. Avoid prolonged exposure to light.
MSDS: Download
Product specifications
Your item has been added. View your cart or proceed to checkout
The count of items is incorrect.