Cyanine7 NHS ester

NHS esters Cyanine7 Near infrared (NIR) imaging Protein labeling
Cat. # Quantity Price Lead time
15020 1 mg $125 in stock
25020 5 mg $260 in stock
45020 25 mg $510 in stock
55020 50 mg $895 in stock
65020 100 mg $1490 in stock
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Amine reactive Cyanine7, near infrared fluorescent dye, an improved analog of Cy7®.

NIR fluorophores can be used to take advantage of near infrared window of biological tissues - increased transparency of tissues in this spectral region allows to carry out in vivo imaging.

This reagent can be utilized to produce Cyanine7-labeled biomolecules for subsequent use in various in vivo research, and drug design related experiments.

The structure of Cyanine7 features rigidized design of central polymethyne chain. This molecular reinforcement allows to increase quantum yield by 20% compared with parent structure, increasing fluorescence brightness.

This reagent requires organic co-solvent for the labeling (please see Recommended Protocols section below). Water-soluble Cyanine7 NHS ester is also available, and recommended for protein NIR labeling.

Cyanine7 NHS ester
Cyanine7 NHS ester
Cyanine7 NHS ester
Cy7 NHS ester structure
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Cy7 absorbance and emission spectra

Cy7 absorbance and emission spectra

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General properties

Appearance: dark green solid
Molecular weight: 733.64
CAS number: 2408482-09-5
Molecular formula: C41H48N3BF4O4
Solubility: soluble in organic solvents (DMSO, DMF, dichloromethane), low solubility in water
Quality control: NMR 1H, HPLC-MS (95%)
Storage conditions: Storage: 12 months after receival at -20°C in the dark. Transportation: at room temperature for up to 3 weeks. Avoid prolonged exposure to light. Desiccate.
MSDS: Download
Product specifications

Spectral properties

Excitation/absorption maximum, nm: 750
ε, L⋅mol−1⋅cm−1: 199000
Emission maximum, nm: 773
Fluorescence quantum yield: 0.3
CF260: 0.022
CF280: 0.029

Product citations

  1. Seo, H.S.; Han, J.-H.; Lim, J.; Bae, G.-H.; Byun, M.J.; Wang, C.-P.J.; Han, J.; Park, J.; Park, H.H.; Shin, M.; Park, T.-E.; Kim, T.-H.; Kim, S.-N.; Park, W.; Park, C.G. Enhanced Post-Surgical Cancer Treatment Using Methacrylated Glycol Chitosan Hydrogel for Sustained DNA/Doxorubicin Delivery and Immunotherapy. Biomaterials Research, 2024, 28, 0008. doi: 10.34133/bmr.0008
  2. Huang, Y.; Wang, J.; Mancino, V.; Pham, J.; O’Grady, C.; Li, H.; Jiang, K.; Chin, D.; Poon, C.; Ho, P.-Y.; Gyarmati, G.; Peti-Peterdi, J.; Hallows, K.R.; Chung, E.J. Oral delivery of nanomedicine for genetic kidney disease. PNAS Nexus, 2024, 3(5), pgae187. doi: 10.1093/pnasnexus/pgae187
  3. Son, T.; Kim, M.; Choi, M.; Nam, S.H.; Yoo, A.; Lee, H.; Han, E.H.; Hong, K.S.; Park, H.S. Advancing fluorescence imaging: enhanced control of cyanine dye-doped silica nanoparticles. Journal of Nanobiotechnology, 2024, 22, 347. doi: 10.1186/s12951-024-02638-7
  4. Colli, C.; Masi, I.; Jacchetti, E.; Santoni, S.; Sponchioni, M.; Colosimo, B.M.; Rosanò, L.; Raimondi, M.T.; Mauri, E.; Moscatelli, D. Zwitterionic nanoparticles for thermally activated drug delivery in hyperthermia cancer treatment. Nanoscale, 2024, 16(26), 12635-12649. doi: 10.1039/d4nr00723a
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Cy® is a trademark of GE Healthcare.
This Product is offered and sold for research purposes only. It has not been tested for safety and efficacy in food, drug, medical device, cosmetic, commercial or any other use. Supply does not express or imply authorization to use for any other purpose, including, without limitation, in vitro diagnostic purposes, in the manufacture of food or pharmaceutical products, in medical devices or in cosmetic products.
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